Amplified cancer target genes useful in diagnosis and...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01) A01N 61/00 (2006.01) A61K 39/395 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2510774

A gene useful as a prognostic indicator of survival of patients afflicted with cancers such as breast cancer is described. Also disclosed are methods for screening potential therapeutic agents, such as antitumor agents, based on their modulation of the expression of a TRIP13 gene, or splice variants thereof, along with methods for diagnosing cancerous, or potentially cancerous, conditions as a result of the expression, or patterns of expression, of such genes, including changes in copy number. Also disclosed are methods for detecting or determining functionally related genes, where disruption of TRIP13 may affect such related-gene expression, as well as methods for treating cancer based on targeting expression products of such genes and determining genes involved in the cancerous process. Methods for identifying, detecting and following patients and others having high levels of amplification/expression of the gene before treatment where differences after treatment serve as markers for indication of success of treatment or for identifying individuals who would benefit from such treatment using this gene marker as a diagnostic and/or prognostic and/or pharmacodynamic or surrogate marker are described.

L'invention concerne l'utilisation d'un gène comme indicateur pronostique de la survie de patients atteints d'un cancer, tel que le cancer du sein. L'invention concerne également des méthodes de criblage d'agents thérapeutiques potentiels, tels que des agents antitumoraux, sur la base de leur capacité à moduler l'expression du gène TRIP13, ou leurs variants d'épissage, ainsi que des méthodes de diagnostic d'états cancéreux ou potentiellement cancéreux, en fonction de l'expression ou de schémas d'expression de ces gènes, y compris des variations dans le nombre de copies. L'invention concerne également des méthodes de détection ou de détermination de gènes associés fonctionnellement, l'interruption de TRIP13 pouvant affecter l'expression du gène associé, ainsi que des méthodes de traitement du cancer fondées sur le ciblage de produits d'expression de ces gènes et la détection de gènes impliqués dans le processus cancéreux. L'invention concerne également des méthodes d'identification, de détection et de suivi de patients et analogues ayant des taux élevés d'amplification/expression du gène avant le traitement, les différences après le traitement servant de marqueurs indiquant le succès du traitement ou à identifier des individus qui pourraient bénéficier d'un tel traitement à l'aide de ce marqueur de gène comme marqueur diagnostique et/ou pronostique et/ou pharmacodynamique ou substitut.

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