Amplified oncogenes and their involvement in cancer

Details Amplified oncogenes and their involvement in cancer Amplified oncogenes and their involvement in cancer

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12P 19/34 (2006.01)

Patent

CA 2459183

There are disclosed methods and compositions for the diagnosis, prevention, and treatment of tumors and cancers in mammals such as humans, utilizing the Galanin, Galanin Receptor 2 (GALR2) and Galanin Receptor 3 (GALR3) genes, which are amplified in breast and/or lung and/or brain and/or colon and/or prostate and/or ovarian cancer genes. The Galanin, GALR2 and GALR3 genes and their expressed protein products and antibodies are used diagnostically or as targets for cancer therapy or vaccine; they are also used to identify compounds and reagents useful in cancer diagnosis, prevention, and therapy. There is also disclosed a GALR2-GALR3 heterocomplex formation during tumorigenesis.

La présente invention concerne des procédés et des compositions destinés au diagnostic, à la prévention et au traitement de tumeurs et de cancers chez des mammifères tels que les humains, par utilisation du gène de la galanine, du gène du récepteur 2 de la galanine (GALR2) et du gène du récepteur 3 de la galanine (GALR3) qui sont amplifiés dans les gènes du cancer du sein, et/ou du poumon, et/ou du cerveau, et/ou de la prostate, et/ou des ovaires. Le gène de la galanine, le GALR2 et le GALR3, ainsi que leurs produits protéines exprimés et anticorps s'utilisent en diagnostic ou comme cibles pour les traitements ou vaccins contre le cancer. On les utilise également pour identifier des composés et réactifs convenant au diagnostic, à la prévention et au traitement du cancer. L'invention concerne également une formation hétérocomplexe GALR2-GALR3 pendant l'oncogenèse.

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