Amplifying the expression of recombinant dna products

Details Amplifying the expression of recombinant dna products Amplifying the expression of recombinant dna products

C - Chemistry, Metallurgy

12

N

530/13, 195/1.23

C12N 15/10 (2006.01) A61K 38/19 (2006.01) A61P 7/00 (2006.01) C07K 14/535 (2006.01) C12N 15/19 (2006.01) C12N 15/27 (2006.01) C12N 15/66 (2006.01) C12P 19/34 (2006.01)

Patent

CA 1341150

Amplified expression of recombinant DNA products is achieved in hosts expressing protease that cleave at multi-basic amino acid residues. To this end, wild-type genes encoding the desired protein products, for example, human granulocyte macrophage colony stimulating factor (GM-CSF), are mutated by substituting codons or eliminating codons encoding multi-basic amino acid residues while maintaining the activity of the expressed protein product. Mutation of the desired gene can be conveniently carried out by site-specific in vitro mutagenisis. GM-CSF is potentially therapeutically useful in treating, for example, proliferative blood disorders, such as certain leukemias and anemias.

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