A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/47 (2006.01) A61K 38/54 (2006.01) C12N 9/28 (2006.01)
Patent
CA 2612811
The pharmaceutical use of amylases related to Bacillus alpha-amylases of SEQ ID NOs: 1-3, optionally in combination with a lipase and/or a protease. Examples of medical indications are: Treatment of digestive disorders, pancreatic exocrine insufficiency (PEI), pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II. The amylases of SEQ ID NOs: 1-3 are variants of amylases from Bacillus stearothermophilus, Bacillus licheniformis and Bacillus sp. The amylases of the invention have an improved efficacy in vivo, an improved pH-profile, a high specific activity, and/or an improved starch degradation profile.
L'utilisation pharmaceutique d'amylases associées aux alpha-amylases Bacillus de SEQ ID NO: 1-3, éventuellement combinée à une lipase et/ou protéase permet le traitement de troubles digestifs, de l'insuffisance exocrine pancréatique (PEI), de la pancréatite, de la fibrose cystique, du diabète de type I et/ou de type II. Les amylases de SEQ ID NO: 1-3 sont des variantes d'amylases provenant de Bacillus stearothermophilus, de Bacillus licheniformis et de Bacillus sp. Les amylases de cette invention présentent une efficacité améliorée in vivo, un profil pH amélioré, une activité spécifique plus élevée et/ou un profil de dégradation d'amidon amélioré.
Gregory Peter Colin
Svendsen Allan
Norton Rose Canada S.e.n.c.r.l.,s.r.l./llp
Novozymes A/s
Solvay Pharmaceuticals Gmbh
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