Amylin aggregation inhibitors and use thereof

Details Amylin aggregation inhibitors and use thereof Amylin aggregation inhibitors and use thereof

C - Chemistry, Metallurgy

07

K

C07K 14/575 (2006.01) A61K 38/22 (2006.01) A61P 5/48 (2006.01) C07K 7/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2516726

Short peptides and derivatives or analogs thereof for the treatment or prevention of lAAP related disorders, in particular amyloid deposits associated with Type I or Type II diabetes arc herein described. These peptides and/or their derivatives have been designed to inhibit the formation of amylin fibrils which arc implicated in the pathogenesis of diabetes Type Il as well as to dissolve the fibrillar deposits already formed

Peptides courts et dérivés ou analogues desdits peptides qui sont destinés à traiter ou à prévenir des troubles liés à lAAP, en particulier des dépôts amyloïdes associés au diabète de type I ou de type II. Ces peptides et / ou leurs dérivés ont été conçus pour inhiber la formation de fibrilles d'amyline qui sont impliquées dans la pathogenèse du diabète de type II, ainsi que pour dissoudre les dépôts fibrillaires déjà formés.

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