Amylin and calcitonin gene-related peptide use and...

Details Amylin and calcitonin gene-related peptide use and... Amylin and calcitonin gene-related peptide use and...

C - Chemistry, Metallurgy

12

N

C12N 5/06 (2006.01) A61K 38/22 (2006.01) C07K 14/575 (2006.01) C12Q 1/02 (2006.01) G01N 33/60 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2063005

AMYLIN AND CALCITONIN GENE-RELATED PEPTIDE USE AND ANTAGONISTS THEREOF Abstract This invention relates to the use of amylin or calcitonin gene-related peptide (CGRP) to reduce insulin stimulated glycolysis in muscle or muscle cells. This invention also relates to a method for assaying the ability of a compound to inhibit the reduction in insulin stimulated glycolysis in muscle or muscle cells caused by amylin or CGRP. Further, this invention relates to compounds capable of inhibiting the reduction in insulin stimulated glycolysis in muscle or muscle cells caused by amylin or CGRP. This invention also relates to pharmaceutical compositions and methods for inhibiting the reduction in insulin stimulated glycolysis in muscle or muscle cells in a mammal caused by amylin or CGRP.

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