Amylin family peptides and methods for making and using them

Details Amylin family peptides and methods for making and using them Amylin family peptides and methods for making and using them

C - Chemistry, Metallurgy

07

K

C07K 14/585 (2006.01)

Patent

CA 2556226

The present invention relates to novel compounds having a function of a peptide in the amylin family, related nucleic acids, expression constructs, host cells, and processes production of the compounds. The compounds of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent metabolic disorders such as obesity, diabetes, and increased cardiovascular risk.

La présente invention concerne de nouveaux composés présentant une fonction d'un peptide dans la famille amyline, des acides nucléiques associés, des produits de synthèse d'expression, des cellules hôtes et des procédés de production desdits composés. Les composés de l'invention comportent une ou plusieurs modifications de séquence d'acides aminés. Cette invention concerne également des méthodes et des compositions pour traiter et prévenir des troubles métaboliques, tels que l'obésité, le diabète et le risque cardiovasculaire accru.

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