Amylin muteins

Details Amylin muteins Amylin muteins

C - Chemistry, Metallurgy

12

Q

C12Q 1/02 (2006.01) A61K 38/17 (2006.01) A61K 38/22 (2006.01) C07K 14/435 (2006.01) C07K 14/575 (2006.01) C12Q 1/54 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2141203

This invention relates to muteins of amylin and derivatives thereof having insulin action suppressing activity as well as the pharmaceutically-acceptable salts thereof. The muteins and derivatives of this invention are useful for suppressing insulin action in muscle or muscle cells and for suppressing insulin action in a mammal in need thereof. Thus, this invention further relates to a method of suppressing insulin action in a mammal in need thereof and methods for suppressing insulin action in muscle or mus- cle cells as well as pharmaceutical compositions comprising the above described muteins, derivatives or salts. This invention also relates to a method for assaying the ability of a compound to inhibit the suppression of insulin action in muscle or muscle cells caused by amylin.

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