Amyloid beta-peptides and methods of use thereof

Details Amyloid beta-peptides and methods of use thereof Amyloid beta-peptides and methods of use thereof

C - Chemistry, Metallurgy

07

K

C07K 14/74 (2006.01) A61K 35/12 (2006.01) A61K 39/00 (2006.01) A61P 25/28 (2006.01) A61P 37/04 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2736729

The present invention relates to polypeptides, compositions, and methods of use thereof for optimized treatment of diseases or disorders associated with amyloid beta protein (A.beta.) accumulation in a subject. This invention also relates to polypeptides, compositions, and methods of use thereof for optimized immunization against diseases characterized by A.beta. accumulation in a subject. This invention further relates to pharmaceutical formulations comprising these polypeptides and methods of use for administering to a subject an optimized A.beta. peptide that elicits a beneficial T cell response; for example, a T cell response reducing A.beta. accumulation in the brain of a subject, without causing an encephalitic response.

L'invention concerne des polypeptides, des compositions, et leurs procédés d'utilisation dans le traitement optimisé de maladies ou de troubles associés à l'accumulation chez un patient de béta-protéines amyloïdes (Aß). L'invention concerne également des polypeptides, des compositions et leurs procédés d'utilisation dans l'immunisation optimisée contre des maladies caractérisées par une accumulation d'Aß chez un patient. L'invention concerne également des formulations pharmaceutiques comprenant lesdits polypeptides ainsi que des procédés d'utilisation comprenant l'administration à un patient d'un peptide d'Aß optimisé qui déclenche une réponse des lymphocytes T bénéfique; par exemple, une réponse de lymphocytes T qui réduit l'accumulation d'Aß dans le cerveau d'un patient, sans entraîner de réponse encéphalique.

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