C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2279555
The invention provides amyloid beta-derived dementing ligands (ADDLs) that comprise amyloid .beta. protein assembled into globular non-fibrillar oligomeric structures capable of activating specific cellular processes. The invention also provides methods for assying the formation, presence, receptor protein binding and cellular activity of ADDLs, as well as compounds that block the formation or activity of ADDLs, and methods of identifying such compounds. The invention further provides methods of using ADDLs, and modulating ADDL formation and/or activity, inter alia in the treatment of learning and/or memory disorders.
L'invention concerne des ligands neurodégénératifs dérivés de l'amyloïde .beta. (ADDL) contenant une protéine amyloïde .beta., assemblée dans des structures oligomères globulaires non fibrillaires capables d'activer des processus cellulaires spécifiques. L'invention concerne également des procédés de détermination de la formation, de la présence, de la liaison du récepteur protéique et de l'activité cellulaire des ADDL, ainsi que des composés bloquant la formation ou l'activité des ADDL et des procédés d'identification de tels composés. En outre, l'invention concerne des procédés d'utilisation des ADDL et de modulation de la formation et/ou de l'activité des ADDL, notamment dans le traitement des troubles d'apprentissage et/ou de la mémoire.
Barlow Ann
Chromy Brett A.
Finch Caleb E.
Klein William L.
Krafft Grant A.
Borden Ladner Gervais Llp
Northwestern University
The University Of Southern California
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