C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 38/04 (2006.01) A61K 38/17 (2006.01) C12Q 1/02 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2381323
The invention provides amyloid beta-derived dementing ligands (ADDLs) that comprise amyloid .beta. protein assembled into globular non-fibrillar oligomeric structures capable of activating specific cellular processes. The invention also provides methods for assaying the formation, presence, receptor protein binding and cellular activity of ADDLs, as well as compounds that block the formation or activity of ADDLs, and methods of identifying such compounds. The invention further provides methods of using ADDLs, and modulating ADDL formation and/or activity, inter alia in the treatment of learning and/or memory disorders.
L'invention concerne des ligands de la démence dérivés d'amyloïde beta (ADDL) comprenant une protéine d'amyloïde beta qui forme des structures oligomères globulaires non fibrillaires capables d'activer des processus cellulaires spécifiques. L'invention concerne également des méthodes d'analyse de la formation, de la présence et de la liaison à la protéine du récepteur et de l'activité cellulaire des ADDL ainsi que des composés bloquant la formation ou l'activité des ADDL et des méthodes d'identification de ces composés. L'invention concerne en outre des méthodes d'utilisation des ADDL et de modulation de la formation et/ou de l'activité des ADDL, notamment pour le traitement de troubles liés à l'apprentissage et/ou à la mémoire.
Barlow Ann
Chromy Brett A.
Finch Caleb E.
Klein William L.
Krafft Grant A.
Mbm Intellectual Property Law Llp
Northwestern University
University Of Southern California
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