Amyloid-binding, metal-chelating agents

A - Human Necessities – 61 – K

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Details

A61K 49/10 (2006.01) A61K 31/425 (2006.01) A61K 49/00 (2006.01) A61K 51/04 (2006.01) A61P 25/28 (2006.01) C07D 277/66 (2006.01)

Patent

CA 2514200

The present invention relates to the diagnosis, prevention, and treatment of pathophysiological conditions associated with amyloid accumulation. Bifunctional therapeutic molecules and contrast imaging agents exhibiting a high affinity for amyloid deposits, and pharmaceutical compositions thereof are described. The invention also provides methods of using these bifunctional molecules, contrast imaging agents, and pharmaceutical compositions for detecting the presence of amyloid deposits using imaging techniques; and for preventing or treating amyloidrelated conditions, such as, for example, Alzheimer's disease.

L'invention concerne le diagnostic, la prévention et le traitement de conditions à taux physiologiques associés à une accumulation d'amyloïdes. L'invention concerne également des molécules thérapeutiques bifonctionnelles et des agents d'imagerie de contraste présentant une affinité élevée aux dépôts d'amyloïdes, ainsi que des compositions pharmaceutiques afférentes. Elle concerne aussi des procédés d'utilisation de ces molécules bifonctionnelles, des agents d'imagerie de contraste, et des compositions pharmaceutiques, en vue de détecter la présence de dépôts d'amyloïdes par des techniques d'imagerie; et en vue de prévenir ou de traiter des conditions liées à l'amyloïde, telles que, par exemple, la maladie d'Alzheimer.

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