Amyloid precursor-like protein and uses thereof

Details Amyloid precursor-like protein and uses thereof Amyloid precursor-like protein and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01) A61K 49/00 (2006.01) C07H 21/00 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12P 21/08 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2093735

Abstract The present invention is directed to isolated amyloid precursor-like proteins (APLPs), nucleotide sequences coding for and regulating expression of these protein, antibodies directed against these proteins, and recombinant vectors and host cells containing the genetic sequences coding for and regulating the expression of these protein sequences. The invention is also directed to isolated genomic DNA, cDNA anti-sense RNA, and RNA containing the protein sequence. Antibodies can be used to detect an APLP in biological specimens, including, for example, fluid, serum or tissue samples. APLP1 and APLP2 are candidate genes for late onset familial Alzheimer's disease. A200-05.WP5 01/21/93

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