Amyloid targeting imaging agents and uses thereof

Details Amyloid targeting imaging agents and uses thereof Amyloid targeting imaging agents and uses thereof

A - Human Necessities

61

K

A61K 51/04 (2006.01) A61K 51/08 (2006.01)

Patent

CA 2416617

Amyloid-targeting imaging agents such as radiolabeled amyloid targeting molecules and amyloid targeting molecule-chelator conjugates for imaging, e.g., amyloid plaques in vivo, and/or for the treatment of amyloidosis disorders. The invention provides amyloid-targeting imaging agents that are useful for imaging sites of amyloid disease. Imaging agents of the invention are capable of binding specifically to amyloid plaques, as an aid in diagnosis and/or early treatment of amyloidosis disorders.

Agents d'imagerie ciblant les substances amyloïdes, tels que des molécules ciblant les substances amyloïdes radiomarquées et des conjugués chélateur-molécule ciblant les substances amyloïdes pour produire des images, par ex. de plaques amyloïdes in vivo, et / ou pour traiter l'amylose. La présente invention concerne des agents d'imagerie ciblant les substances amyloïdes, utiles pour produire des images de sites d'amylose. Les agents d'imagerie selon la présente invention sont capables de se lier spécifiquement aux plaques amyloïdes, et sont utilisés pour le diagnostic et / ou le traitement précoce de l'amylose.

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