An activation epitope of fcgammarii (cd32), binding...

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G01N 33/564 (2006.01) C07K 16/28 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2675889

The present invention provides means and method for detecting an activation epitope on FcyRII (CD32) on Fc.gamma. (CD32) expressing cells. The presence of epitope on Fc.gamma.RII (CD32) correlates with priming of the cell containing Fc.gamma.RII (CD32) expressing said epitope. The invention further provides binding molecules specific for said activation epitope on Fc.gamma.RII (CD32), and uses thereof in the detection of activated cells. Further uses are the treatment of individuals suffering from inflammation or at risk of suffering thereof. Also provided, among others, are uses for detecting and/or following an inflammation in an individual.

La présente invention propose un moyen et un procédé pour détecter un épitope d'activation de Fc.gamma.RII (CD32) sur des cellules exprimant Fc.gamma. (CD32). La présence de l'épitope sur Fc.gamma.RII (CD32) concorde avec l'amorçage de la cellule contenant Fc.gamma.RII (CD32) exprimant l'épitope. L'invention propose en outre des molécules de liaison spécifiques pour l'épitope d'activation sur Fc.gamma.RII (CD32), et des utilisations de celles-ci dans la détection de cellules activées. Elles sont utilisées par ailleurs pour le traitement d'individus souffrant d'inflammation ou courant le risque d'en souffrir. L'invention propose enfin, entre autres choses, des utilisations pour la détection et/ou le suivi d'une inflammation chez un individu.

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