C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 231/24 (2006.01) B01J 20/22 (2006.01) C07C 237/46 (2006.01)
Patent
CA 2710585
This invention relates generally to non-ionic X-ray contrast agents. It further relates to a method of using solid adsorbents to reduce backpeaks content in the purification of iodixanol. In particular, it relates to the use of non-polar organic adsorbents with the average pore diameter smaller than about 30 nm. Specific examples of adsorbents of the instant invention include non-polar acrylic ester, di-vinyl benzene resins, poly- styrene di-vinyl benzene resins, and carbon adsorbents. In certain embodiments, upwards of 30% of the backpeak levels and 60% N-acetyl cyclic iodixanol levels are reduced for a 5% loss of iodixanol.
Holmaas Lars Terje
Homestad Ole Magne
Malthe-Sorenssen Didrik
Pressman Eric
Stella Albert Santo
Fetherstonhaugh & Co.
Ge Healthcare As
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