An agent comprising fgf2 as an effective ingredient for...

A - Human Necessities – 61 – K

Patent

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A61K 38/18 (2006.01)

Patent

CA 2566400

The present invention relates an agent comprising FGF2(Fibroblast Growth Factor-2 or basic Fibroblast Growth Factor(bFGF)) as an effective ingredient for treatment or prevention of Asthma and Chronic Obstructive Pulmonary Disease(COPD). Also, The present invention relates Th1 asthma and COPD mouse animal model induced by Ovalbumin and double strand RNA. The therapeutic agent comprising FGF2 of the present invention can be used for treatment or prevention for airway fibrosis, airway inflammation, airway hyperresponsiveness, airway remodeling, asthma and COPD. Also, Th1 asthma and COPD mice animal model induced by Ovalbumin and double strand RNA can be used for development of therapeutic agent for asthma and COPD.

La présente invention concerne un agent comprenant le FGF2 (le facteur de croissance des fibroblastes 2 ou le facteur de croissance des fibroblastes basique (bFGF)) comme ingrédient actif pour le traitement ou la prévention de l'asthme et de la bronchopneumopathie chronique obstructive (BPCO). La présente invention concerne également le modèle animal murin de la BPCO et de l'asthme Th1 induit par l'ovalbumine et un ARN double brin. L'agent thérapeutique comprenant le FGF2 de la présente invention peut être utilisé pour le traitement ou la prévention des fibroses pulmonaires, des inflammations pulmonaires, de l'hypersensibilité pulmonaire, du remodelage pulmonaire, de l'asthme et de la BPCO. Par ailleurs, le modèle animal murin de la BPCO et de l'asthme Th1 induit par l'ovalbumine et l'ARN double brin peut être utilisé pour la mise au point d'un agent thérapeutique destiné au traitement de l'asthme et de la BPCO.

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