An agent for increasing chemokine production

Details An agent for increasing chemokine production An agent for increasing chemokine production

A - Human Necessities

61

K

A61K 39/285 (2006.01) A61K 35/12 (2006.01) A61K 35/36 (2006.01)

Patent

CA 2300792

The present invention is to offer am agent for increasing chemokine production which is useful for the treatment of AIDS. The effective component of the agent of the present invention for increasing chemokine production is an extract from inflammatory tissue inoculated with vaccinia virus. The extracts from inflammatory tissue inoculated with vaccinia virus increase the production of chemokines such as MIP-1.alpha., MIP-1.beta. and RANTES which are HIV-suppressive factors released from CD8+T cells. The extracts also have suppressive effects on SIV infection and on SIV replication. Therefore, the agent of the present invention containing such extract is useful as an anti-HIV drug with new mechanism of action different from those of known therapeutic agents for AIDS, such as reverse transcriptase inhibitors and protease inhibitors. The agent of this invention is very useful as a new drug for the treatment of AIDS with high safety.

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