An agent for preventing and/or treating hematologic...

Details An agent for preventing and/or treating hematologic... An agent for preventing and/or treating hematologic...

A - Human Necessities

61

K

A61K 38/08 (2006.01) A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2534461

In the present invention, a useful molecular target for a specific immunotherapy of hematologic malignancies was found, and a means capable of preventing and/or treating hematologic malignancies was provided. Specifically, provided were the followings: an agent for preventing and/or treating hematologic malignancies comprising as an active ingredient at least one peptide having an amino acid sequence selected from any one of SEQ ID NOs: 1 to 10 in the sequence listing; the agent for preventing and/ or treating hematologic malignancies further comprising an adjuvant; and the preventing and/ or treating agent to use as a cancer vaccine for hematologic malignancies, which allowed prevention and/or treatment of hematologic malignancies such as an HLA-A24 positive hematologic malignancies or the hematologic malignancies that are HLA-A24 positive and express a protein containing the peptide.

L'invention porte sur la recherche d'une molécule cible qui est utile dans une thérapie immune spécifique d'une tumeur hématopoïétique et sur un moyen permettant de prévenir et/ou traiter la tumeur hématopoïétique. L'invention porte notamment sur un agent préventif et/ou remède pour tumeur hématopoïétique contenant au moins un peptide possédant une séquence d'acides aminés représentée par un quelconque SEQ ID NO de 1 à 10 dans la liste des séquences comme ingrédient actif. L'agent préventif et/ou remède précité contient également un adjuvant et peut être utilisé comme vaccin contre le cancer. Il est ainsi possible de prévenir et/ou traiter une tumeur hématopoïétique telle qu'une tumeur hématopoïétique positive HLA-A24, tumeur positive par rapport à HLA-A24 et qui exprime une protéine contenant le peptide précité.

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