C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 14/81 (2006.01) C12N 15/11 (2006.01) C12P 19/34 (2006.01) G01N 33/543 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2302829
The disclosed invention relates to a diagnostic method of Alzheimer's disease based on genotyping the Alpha-2-Macroglobulin locus. A statistically significant correlation was found between inheritance of particular alleles of the Alpha-2-Macroglobulin gene and the occurrence of Alzheimer's disease. The diagnostic method involves the isolation of nucleic acid from an individual and subsequent genotyping by means such as sequencing or restriction fragment length polymorphism analysis. The invention also provides a means of genotype analysis through protein isotyping Alpha-2-Macroglobulin variant proteins. Finally, kits for nucleic acid analysis or protein analysis are taught.
La présente invention concerne une méthode diagnostique pour la maladie d'Alzheimer, basée sur le génotypage du locus de l'Alpha-2-macroglobuline. On a trouvé une corrélation statistiquement significative entre la transmission héréditaire d'allèles particuliers du gène Alpha-2-macroglobuline et l'apparition de la maladie d'Alzheimer. Cette méthode diagnostique comprend l'isolement d'acides nucléiques chez un individu, suivi du génotypage, notamment, par séquençage ou analyse du polymorphisme de la longueur des fragments de restriction. L'invention concerne également un moyen de réaliser une analyse du génotype à travers un isotypage protéique de protéines variantes d'Alpha-2-macroglobuline. Enfin, l'invention concerne des kits d'analyse d'acides nucléiques ou d'analyse de protéines.
Blacker Deborah L.
Hyman Bradley T.
Rebeck George W.
Tanzi Rudolph E.
Mbm Intellectual Property Law Llp
The General Hospital Corporation
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