An animal model for identifying a common stem/progenitor to...

Details An animal model for identifying a common stem/progenitor to... An animal model for identifying a common stem/progenitor to...

G - Physics

01

N

G01N 33/53 (2006.01)

Patent

CA 2600821

The invention provides animal models, where the ectopic expression of KGF, EGF, or both is under the control of a pancreas-specific promoter, e.g., the insulin promoter. The expression of KGF in the ins-KGF pancreatic inslets of Langerhans results in enlarged islets, with substantial proliferation of duct cells within the islet mass, and the presence of albumin and alpha-fetoprotein-producing hepatocytes in the islets of the ins-KGF pancreata. The compositions and methods disclosed are useful for identifying and isolating pancreatic stem/progenitor cells, including a common stem/progenitor to liver cells and pancreatic cells.

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