An anthraquinone and its derivatives

Details An anthraquinone and its derivatives An anthraquinone and its derivatives

C - Chemistry, Metallurgy

09

B

C09B 1/515 (2006.01) C07C 225/36 (2006.01) C12Q 1/68 (2006.01) G01N 33/52 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2340670

There is disclosed a compound of formula (I) wherein each of X1 and X2 are independently NH-A-NR1R2, and wherein A is A C2-8 alkylene group and R1 and R2 are independently selected from hydrogen, C1-4 alkyl, C2-4 hydroxy-alkyl and C2-4 aminoalkyl, or R1 and R2 together form a C2-6 alkylene group which with the nitrogen atom to which R1 and R2 are attached forms a heterocyclic ring, or an N-oxide derivative thereof, and wherein the compound (I) or its N-oxide derivative is optionally in the form of an acid salt derived from an organic or inorganic acid. Also disclosed is a method of its production and its uses, including its use in analysing a cell or biological material and detecting the emitted fluorescence signal.

L'invention porte sur un composé de la formule (I) dans laquelle chacun des X1 et X2 représente indépendamment NH-A-NR<1>R<2>, et A représente un groupe alkyléne C2-8 et R<1> et R<2> sont indépendamment sélectionnés parmi hydrogène, alkylC1-4, hydroxy-alkyl C2-4 et aminoalkyl C2-4, ou bien R<1> et R<2>, réunis, forment un groupe alkylène C2-6 qui, avec l'atome d'azote auquel R<1> et R<2> sont liés, forment un noyau hétérocyclique, ou bien un dérivé N-oxyde de celui-ci. Le composé (I) ou son dérivé N-oxyde se présente éventuellement sous la forme d'un sel acide dérivé d'un acide organique ou inorganique. L'invention porte également sur un procédé de production et sur les utilisations de ce composé, y compris son utilisation dans l'analyse d'une cellule ou d'une substance biologique et dans la détection du signal de fluorescence émis.

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