An antibody fragment capable of modulating multidrug...

Details An antibody fragment capable of modulating multidrug... An antibody fragment capable of modulating multidrug...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2520936

An antibody fragment and methods of utilizing same are provided. The antibody fragment includes an antigen binding region capable of binding an extracellular portion of a P-glycoprotein thereby at least partially inhibiting drug efflux activity in multidrug resistant cells.

L'invention concerne un fragment d'anticorps et ses méthodes d'utilisation. Ledit fragment d'anticorps comprend une région de liaison à un antigène capable de se lier à une partie extracellulaire d'une P-glycoprotéine, ce qui permet d'inhiber au moins partiellement l'activité d'écoulement de médicaments dans des cellules résistant à plusieurs médicaments.

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