C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) A01N 43/04 (2006.01) A61K 39/395 (2006.01) C07H 21/02 (2006.01) C07K 16/28 (2006.01) C12N 5/00 (2006.01) C12N 15/00 (2006.01)
Patent
CA 2407965
An antibody of the invention interacts with human DR5 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of anti-DR5 antibodies have been elucidated and vectors and cells containing and expressing these sequences have been generated. Methods and uses for the antibodies are detailed including treatment of apoptosis-related disease and treatment of dysregulated cell growth.
Un anticorps de l'invention interagit avec la DR5 humaine de façon à produire des effets agonistes ou antagonistes en aval du récepteur y compris l'inhibition de la prolifération cellulaire et l'apoptose. Des séquences d'acides nucléiques et des séquences d'acides aminés d'anticorps anti-DR5 ont été élucidées, et des vecteurs et cellules contenant et exprimant ces séquences ont été générés. L'invention concerne également en détail des procédés et des utilisations pour les anticorps, y-compris le traitement d'affections en relation avec l'apoptose et le traitement de croissance cellulaire dérégulée.
Ichikawa Kimihisa
Kimberly Robert P.
Koopman William J.
Zhou Tong
Gowling Lafleur Henderson Llp
Uab Research Foundation
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