An antihistamine antiallergic agent and a method of deriving it

Details An antihistamine antiallergic agent and a method of deriving it An antihistamine antiallergic agent and a method of deriving it

C - Chemistry, Metallurgy

07

D

C07D 473/06 (2006.01) A61P 27/14 (2006.01) A61P 37/08 (2006.01)

Patent

CA 2686525

The invention relates to a range of original xanthine derivatives substituted in 1- and 7- positions with benzhydryl-4-piperazinyl-1-alkane fragments. A method for obtaining 3-methyl-7-[4-(benzhydryl-4-piperazinyl-1) butyl] xanthine and the salts thereof with organic and inorganic acids by alkylating the 7-potassium salt of 3-methylxanthine by 1,4-dibromobutane, by subsequently interacting the thus formed 7-(4-bromobutyl)-3- methylxanthine with 1-benzhydrylpiperazinyl and by neutralising the thus obtained radical 7-/4-(4-benzhydrylpiperazinyl-1) butyl/-3-methylxanthine by an organic or inorganic acid is also disclosed.

L'invention concerne une série de dérivés originaux de xanthine substitués dans les positions 1- et 7- avec des fragments de benzhydryl-4-pipérazinyl-1-alcanes. Elle concerne un procédé de fabrication de 3-méthyl-7-[4-(benzhydryl-4-pipérazinyl-1) butyl] xanthine et de ses sels avec des acides organiques ou inorganiques par l'alkylation du sel 7-sodique de 3-méthylxanthine avec du 1,4-dibromobutane, suivie de l'interaction subséquente de 7-(4-bromobutyl)-3- méthylxanthine ainsi obtenue avec 1-benzhydrylpipérazine et de la neutralisation de la base ainsi obtenue de 7-/4-(4-benzhydrylpipérazinyl-1) butyl/-3-méthylxanthine par un acide organique ou inorganique.

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