A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/52 (2006.01) A61K 9/107 (2006.01) A61K 47/00 (2006.01)
Patent
CA 2142493
An antivirally active pharmaceutical oil-in-water emulsion containing 9-[(2-hydroxyethoxy)methyl]gua- nine (acyclovir) or a salt or ester thereof as an active in- gredient in the continuous aqueous phase, said phase in addition to said active ingredient and the dispersed oil phase containing a water miscible organic solvent, wherein a polyhydric alcohol may form a constituent. The emulsion comprises from 1 % to 10 % w/w of acyc- lovir or a salt or ester thereof, from 20 % to 50 % w/w of organic solvent comprising from 5 % to 50 % w/w gly- cerol formal and from 0 % to 29 % w/w of a polyhydric alcohol, and from 20 % to 40 % w/w water, said percen- tages being based on the total weight of the formula- tion. As a polyhydric alcohol propylene glycol may be used, and the emulsion may be available as a cream, wherein the oil phase comprises white vaseline, liquid paraffin (paraffin oil), glycerol monostearate, and stea- ric acid.
Alhede Bõrge Ingvar Frisch
Bjornsdottir Karen
Gebhard-Hansen Knud Erik
Lissau Bodil Gyllembourg
Pedersen Soren Bols
A/s Gea Farmaceutisk Fabrik
Macrae & Co.
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