An attenuated strain of leptospira not expressing the loa22...

C - Chemistry – Metallurgy – 12 – N

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C12N 1/20 (2006.01) A61K 35/74 (2006.01) A61K 39/02 (2006.01) A61P 31/04 (2006.01) C12N 1/21 (2006.01) C12N 1/36 (2006.01) C07K 14/20 (2006.01)

Patent

CA 2589155

The present invention related to an attenuated strain of Leptospira species which does not allow expression of the Loa22 protein. The present invention also related to the use of the mutant Leptospira strain in compositions and methods for the treatment and/or prevention of a leptospiral disease.

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