An efficient synthesis of furan sulfonamide compounds useful...

Details An efficient synthesis of furan sulfonamide compounds useful... An efficient synthesis of furan sulfonamide compounds useful...

C - Chemistry, Metallurgy

07

D

C07D 307/64 (2006.01) C07D 307/68 (2006.01)

Patent

CA 2278988

An efficent synthesis of furan sulfonamide compounds of formula (see formula I) comprising reacting a compound of formula II with a Grignard reagent in a reaction inert solvent, wherein R' is (C1-C6)alkyl. The compound of formula II is prepared by reacting a compound of formula III with a compound of formula IV wherein R' is (C1- C6)alkyl with a chorinating reagent and an acid scaverger in an inert solvent. The invention also includes a novel compound of the formula (see formula VI) wherein R' is (C1-C6)alkyl and Q is halo, hydroxy or amino.

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