An enantioselective synthesis of pyrrolidine-substituted...

Details An enantioselective synthesis of pyrrolidine-substituted... An enantioselective synthesis of pyrrolidine-substituted...

C - Chemistry, Metallurgy

07

D

C07D 405/04 (2006.01) C07D 207/08 (2006.01)

Patent

CA 2658215

The present invention relates to an enantioselective synthesis of (+)-trans enantiomer of pyrrolidines substituted with flavones, represented by Formula 1 or salts thereof, which are inhibitors of cyclin dependant kinases and can be used for treatment of proliferative disorders such as cancer. wherein Ar has the meaning as indicated in the claims.

La présente invention concerne une synthèse énantiosélective d'énantiomères (+)- trans de pyrrolidines substituées par des flavones, représentées par la formule 1, ou de sels de celles-ci. Il s'agit d'inhibiteurs des kinases cycline-dépendantes qui peuvent être utilisés pour le traitement d'affections prolifératives comme le cancer, Ar étant tel que défini dans les revendications.

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