An endogenous peptide and active subfragments thereof

Details An endogenous peptide and active subfragments thereof An endogenous peptide and active subfragments thereof

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 38/17 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2531240

The present invention relates to a substantially pure biologically active consecutive anti-angiogenic polypeptide comprising the central region of human Histidine Rich Glycoprotein (HRGP). Said polypeptide is shown to comprise a potential endogenous, naturally occurring subfragment of human HRGP, comprising similar anti-angiogenic activities as the mature protein. The present invention also relates to one or more new biologically active subfragments of human HRGP, derived from said central region. Said subfragments are all characterized by having anti-angiogenic activity. One of the active subfragments is referred to as Pep2. Enscoped by the present invention are also anti-angiogenic subfragments derived from Pep2, one of them comprising a newly identified presently minimal functional entity.

La présente invention a trait à un polypeptide anti-angiogénique consécutif présentant une activité biologique sensiblement pure comprenant la région centrale de la glycoprotéine humaine riche en histidine. On a observé que ledit polypeptide comporte un sous-fragment naturel endogène potentiel de la glycoprotéine humaine riche en histidine, comprenant des activités anti-angiogéniques comme la protéine mature. La présente invention a également trait à un ou des sous-fragments nouveaux biologiquement actifs de la glycoprotéine humaine riche en histidine, dérivés de ladite région centrale. Lesdits sous-fragments sont tous caractérisés en ce qu'ils présentent une activité anti-angiogénique. Un des sous-fragments actifs est désigné Pep2. La présente invention à trait en outre aux sous-fragments anti-angiogéniques dérivés de Pep2, dont un comporte une entité fonctionnelle actuellement minimale récemment identifiée.

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