An engineered recombinant molecule that regulates humoral...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) A01K 67/00 (2006.01) C07K 14/705 (2006.01) C07K 19/00 (2006.01) C12N 5/06 (2006.01) C12N 5/10 (2006.01) C12N 15/10 (2006.01) C12N 15/62 (2006.01) C12N 15/66 (2006.01)

Patent

CA 2361646

Recombinant chimeric molecules that include at least a domain capable of regulating the humoral effector functions of the immune system and another domain capable of regulating the cellular effector functions of the immune system are provided. Recombinant DNA constructs having DNA sequences encoding the above mentioned chimeric proteins are provided. Cloning vectors incorporating the above DNA constructs and cells transformed with the vectors and host cells containing such vectors are also provided. Transgenic cells, tissues, organs, and animals incorporating the above-mentioned chimeric molecules are provided.

L'invention concerne des molécules chimériques de recombinaison, comprenant au moins un domaine capable de réguler les fonctions effectrices humorales du système immunitaire, un autre domaine capable de réguler les fonctions effectrices cellulaires dudit système immunitaire. L'invention concerne également des constructions d'ADN de recombinaison possédant des séquences d'ADN codant pour les protéines chimériques précitées. Elle concerne, en outre, des vecteurs de clonage incorporant les constructions d'ADN précitées, des cellules transformées à l'aide de ces vecteurs, et des cellules hôtes contenant lesdits vecteurs. Elle concerne enfin des cellules transgéniques, des tissus, des organes, et des animaux incorporant les molécules chimériques précitées.

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