An enzyme regulating ether lipid signaling pathways

Details An enzyme regulating ether lipid signaling pathways An enzyme regulating ether lipid signaling pathways

C - Chemistry, Metallurgy

12

Q

C12Q 1/34 (2006.01) A61K 31/00 (2006.01) A61K 31/27 (2006.01) A61P 35/00 (2006.01) G01N 33/567 (2006.01) C12N 9/16 (2006.01) C12N 9/99 (2006.01)

Patent

CA 2665223

A multidimensional profiling strategy that combines activity-based proteomics and metabolomics was used to determine that an active protein, which is a previously uncharacterized enzyme highly elevated in aggressive cancer cells, serves as a central node in an ether lipid signaling network that bridges platelet-activating factor and the lysophospholipids. Biochemical studies confirmed that the active protein regulates this pathway by hydrolyzing the metabolic intermediate 2-acetyl monoalkylglycerol. Inactivation of the active protein disrupted ether lipid metabolism in cancer cells and impaired cell migration and tumor growth in vivo.

Selon l'invention, on a utilisé une technique de profilage multidimensionnel combinant la protéomique basée sur l'activité et la métabolomique pour établir qu'une protéine active, soit une enzyme non caractérisée précédemment dont la concentration est très élevée dans les cellules cancéreuses agressives, sert de noeud central dans un réseau de signalisation des lipides d'éther formant un pont entre le facteur d'activation plaquettaire et les lysophospholipides. Des études biochimiques ont confirmé que cette protéine active régule ladite voie par hydrolyse du 2-acétyl monoalkylglycérol intermédiaire métabolique. L'inactivation de cette protéine active perturbe le métabolisme des lipides d'éther dans les cellules cancéreuses et réduit la migration cellulaire et la croissance tumorale in vivo.

Affiliated with

Also associated with

Rating

An enzyme regulating ether lipid signaling pathways does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with An enzyme regulating ether lipid signaling pathways, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and An enzyme regulating ether lipid signaling pathways will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1517935