An estradiol derivative or an estratopone derivative...

A - Human Necessities – 61 – K

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A61K 9/00 (2006.01) A61K 31/565 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2564948

Biocompatible intraocular implants include an anti-angiogenic agent, such as estradiol derivative or an estratopone and a biodegradable polymer that is effective to facilitate release of the anti-angiogenic agent into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as angiogenisis, ocular tumors, and the like.

Des implants intra-oculaires biocompatibles comprennent un agent anti-angiogenèse, tel qu'un dérivé d'estradiol ou un estratopone et un polymère biodégradable efficace pour faciliter la libération de l'agent anti-angiogenèse dans un oeil sur une période prolongée. Les agents thérapeutiques des implants peuvent être associés à une matrice polymère biodégradable, telle qu'une matrice sensiblement exempte d'alcool polyvinylique. Ces implants peuvent être placés dans un oeil à traiter ou réduire l'apparition d'une ou plusieurs affections oculaires, telles que l'angiogenèse, les tumeurs oculaires et similaire.

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