An ex vivo animal or challenge model as method to measure...

Details An ex vivo animal or challenge model as method to measure... An ex vivo animal or challenge model as method to measure...

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 39/00 (2006.01) C07K 16/40 (2006.01) C12N 1/21 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) G01N 33/48 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2284110

The invention relates to an ex vivo animal or challenge model as a method to identify protective (recombinant) proteins and rapidly measure protective immunity in intestinal segments, directed against parasites and vaccines directed against parasitic infections. The invention further relates to vaccines directed against infection with parasites, such as Fasciola hepatica, which vaccines contain protective (recombinant) proteins identified and shown to be protective in studies using the ex vivo model. The invention further relates to protective (recombinant) proteins derived from newly excysted juveniles (NEJ) of Fasciola hepatica, and relates to the protective (recombinant) protein or fragments thereof corresponding to an NEJ protein with an apparent molecular weight of 32 kD, highest homology to cathepsin L, and an N-terminal amino acid sequence comprising the sequence XXDVSWPFWDRMYNY, in which the amino acids are given in the one letter code.

L'invention concerne un modèle animal ex vivo ou un modèle de provocation utilisé comme méthode pour identifier des protéines (recombinantes) protectrices et pour mesurer rapidement l'immunité protectrice contre les parasites au niveau de l'intestin, ainsi que des vaccins dirigés contre les infections parasitaires. Elle concerne également des vaccins dirigés contre des infections par les parasites, tels que Fasciola hepatica, qui contiennent des protéines (recombinantes) protectrices identifiées et qui se sont avérés protecteurs dans des études utilisant le modèle ex vivo. L'invention concerne également des protéines (recombinantes) protectrices dérivées des formes juvéniles récemment libérées par rupture de kyste (NEJ) de Fasciola hepatica, ainsi que la protéine (recombinante) protectrice ou un de ses fragments correspondant à une protéine NEJ, ayant un poids moléculaire apparent de 32 kD et renfermant une séquence d'acides aminées N-terminale qui comporte la séquence XXDVSWPFWDRMYNY, les acides aminés étant indiqués par leur lettre code.

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