An herpes simplex virus complex

Details An herpes simplex virus complex An herpes simplex virus complex

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 35/76 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/005 (2006.01) C07K 14/82 (2006.01) C07K 16/00 (2006.01) C07K 19/00 (2006.01) C12N 7/00 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2475604

There is provided an HSV complex which comprises an avirulent HSV and a targeting agent which allows the HSV particle to infect and lyse a specific targeted cell. The inventors have found a way in which avirulent HSV can be targeted to disease cells, e.g. cancer cells, by incorporating an antibody binding domain into one or more viral glycoproteins.

L'invention concerne un complexe du virus herpès simplex qui comprend un virus herpès simplex virulent et un agent de ciblage qui permet à la particule du virus herpès simplex d'infecter et d'assurer la lyse d'une cellule ciblée spécifique. Selon l'invention, un virus herpès simplex non virulent peut être ciblé vers les cellules malades, par exemple les cellules cancéreuses, en incorporant un domaine de liaison d'anticorps dans une ou plusieurs glycoprotéines virales.

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