An hiv-1 latency model for high throughput screening

Details An hiv-1 latency model for high throughput screening An hiv-1 latency model for high throughput screening

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/867 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2632456

Isolated, latently infected T cell lines are provided that can be utilized in high throughput screening to discover compounds capable of activating HIV-I. The T cell lines harbor a latent HIV-I derived vector pro virus, which upon activation expresses a marker for late viral gene expression due to the insertion of the marker gene in the position of HIV-I envelope.

L'invention porte sur des lignées cellulaires T infectées de manière latente qui peuvent être utilisées dans le criblage à haut débit dans le but de découvrir des composés capables d'activer le VIH-I. Les lignées cellulaires T hébergent un vecteur dérivé du provirus VIH-1 latent, qui, lorsqu'il est activé, exprime un marqueur de l'expression génique virale tardive provoquée par l'introduction du gène marqueur dans la position de l'enveloppe du VIH-I.

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