An implantable material and a method for the preparation...

A - Human Necessities – 61 – L

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A61L 27/22 (2006.01) A61L 27/36 (2006.01) A61L 27/52 (2006.01) A61L 27/56 (2006.01) C08J 3/07 (2006.01) C08J 9/00 (2006.01) D01C 3/02 (2006.01)

Patent

CA 2723241

A method for the preparation of a regenerated silk fibroin solution comprises the steps of: treating silk or silk co-coons with an ionic reagent comprising an aqueous solution of monovalent cations and monovalent anions, the cations and anions having ionic radii of at least 1.05 Angstroms and a Jones-Dole B coefficient of between -0.001 and -0.05 at 25°C; and subsequent-ly degumming the treated silk or silk cocoons; or alternatively, degumming silk or silk cocoons; and subsequently treating the degummed silk or silk cocoons with an ionic reagent comprising an aqueous solution of monovalent cations and monovalent an-ions, the cations and anions having ionic radii of at least 1.05 Angstroms and a Jones-Dole B coefficient of between -0.001 and -0.05 at 25°C. The invention also extends to fibroin solution, a fibroin material and an implant useful for cartilage repair.

Linvention concerne un procédé de préparation dune solution de fibroïne de soie régénérée, qui comprend les étapes consistant à : traiter de la soie ou des cocons de soie avec un réactif ionique comprenant une solution aqueuse de cations monovalents et danions monovalents, les cations et les anions ayant des rayons ioniques dau moins 1,05 Angströms et un coefficient de Jones-Dole B compris entre -0,001 et -0,05 à 25 °C; puis décreuser la soie ou les cocons de soie traités; ou en variante décreuser de la soie ou des cocons de soie; puis traiter la soie ou les cocons de soie décreusés avec un réactif ionique comprenant une solution aqueuse de cations monovalents et danions monovalents, les cations et les anions ayant des rayons ioniques dau moins 1,05 Angströms et un coefficient de Jones-Dole B compris entre -0,001 et -0,05 à 25 °C. Linvention concerne également une solution de fibroïne, un matériau de fibroïne et un implant utile pour la réparation du cartilage.

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