An improved method for preparation of cefuroxime axetil

Details An improved method for preparation of cefuroxime axetil An improved method for preparation of cefuroxime axetil

C - Chemistry, Metallurgy

07

D

C07D 501/04 (2006.01) C07D 501/34 (2006.01)

Patent

CA 2433067

An improved method for synthesis of cefuroxime axetil of formula (I) in high purity substantially free of the corresponding 2-cephem(.DELTA.2)-ester of formula (II) and other impurities. The compound produced is valuable as a prodrug ester of the corresponding cephalosporin- 4-carboxylic acid derivative i. e. cefuroxime, particularly suitable for oral administration in various animal species and in man for treatment of infections caused by gram-positive and gram-negative bacteria.

L'invention concerne un procédé amélioré de synthèse de céfuroxime axétil de la formule (I) de grande pureté sensiblement libre de 2-céphème(.DELTA.?2¿)-ester correspondant de la formule (II) et d'autres impuretés. Le composé produit est précieux en tant qu'ester de promédicament du dérivé de l'acide céphalosporine-4- carboxylique correspondant, c'est-à-dire le céfuroxime, particulièrement approprié pour administration par voie orale chez diverses espèces animales et chez l'homme aux fins du traitement d'infections provoquées par les bactéries gram positive et gram négative.

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