An improved method for synthesising templated molecules

Details An improved method for synthesising templated molecules An improved method for synthesising templated molecules

C - Chemistry, Metallurgy

12

N

C12N 15/10 (2006.01) C07B 61/00 (2006.01) C07H 21/00 (2006.01) C12P 1/00 (2006.01)

Patent

CA 2518626

The invention relates to a method for synthesising templated molecules attached to the templated which directed the synthesis thereof. The method involves a template, a scaffold functional entity and a functional entity attached to a building block, which, in turn, is attached the template. The scaffold functional entity and the functional entity of the building block are both provided with complementary dimerization domains allowing the functional entities to come into close proximity when the complementary domains interact with to each other. The method may be used for generating libraries of templated molecules which may be selected for biological activity.

L'invention concerne un procédé pour la synthèse de molécules matricées fixées à la matrice de synthèse. On utilise une matrice, une entité fonctionnelle échafaudage et une entité fonctionnelle fixée à un motif structural, lui-même fixé à la matrice. L'entité fonctionnelle échafaudage et l'entité fonctionnelle du motif structural ont chacune des domaines de dimérisation complémentaires permettant aux entités fonctionnelles de se rapprocher étroitement lorsque les domaines complémentaires interagissent. Le procédé considéré peut être utilisé pour l'élaboration de bibliothèques de molécules matricées susceptibles d'être sélectionnées pour une activité biologique.

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