An improved pharmaceutical composition and a process for its...

A - Human Necessities – 61 – K

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A61K 9/52 (2006.01) A61K 9/48 (2006.01) A61K 31/4439 (2006.01)

Patent

CA 2386277

The present invention relates to an improved pharmaceutical composition, in the form of a soft gel capsule resistant to digestive juice. The composition of the present invention is made up of gelatin and an enteric polymer in the form of free acid or its salts, containing a benzimidazole derivative used in the treatment of duodenal ulcers, solubilised and/or suspended in a liquid or semisolid medium, comprising of a hydrophobic carrier, an alkaline inert reacting material and a surface active agent and/or a solubilising agent. The present invention also relates to a method for preparing the above said pharmaceutical composition.

La présente invention concerne une composition pharmaceutique améliorée sous la forme d'une gélule souple résistant aux sucs digestifs. La composition selon l'invention est composée de gélatine et d'un polymère entérique sous forme d'un acide libre ou de son sel, contenant un dérivé de benzimidazole utilisé dans le traitement d'ulcères duodénaux, solubilisé et/ou suspendu dans un liquide ou un milieu semi-solide composés d'un porteur hydrophobe, d'un matériau réactif inerte alcalin, et d'un tensioactif et/ou d'un agent solubilisant. La présente invention concerne également un procédé de préparation de ladite composition pharmaceutique.

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