C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 253/06 (2006.01) C07D 253/075 (2006.01)
Patent
CA 2334937
There is disclosed an improved process for the preparation of 3,5-diamino-6- (2,3-dichlorophenyl)-1,2,4-triazine which process comprises the step of reacting 2,3-dichlorobenzoylchloride with cuprous cyanide in presence of acetonitrile and a cosolvent to produce dichlorobenzoyl cyanide said dichlorobenzoyl cyanide is reacted with aminoguanidine bicarbonate to produce an intermediate product, which is cyclized in presence of aqueous potassium hydroxide to produce 3,5-diamino- 6-(2,3-dichlorophenyl)-1,2,4-triazine.
L'invention porte sur un procédé amélioré de préparation de 3,5-diamino-6-(2,3-dichlorophényl)-1,2,4-triazine consistant à faire réagir du 2,3-dichlorobenzoylchlorure avec du cyanure de cuivre en présence d'acétonitrile et d'un cosolvant, ce qui donne du cyanure de dichlorobenzoyle qu'on fait réagir avec du bicarbonate d'aminoguanidine pour donner un produit intermédiaire cyclisé en présence d'hydroxyde aqueux de potassium pour donner le 3,5-diamino-6-(2,3-dichlorophényl)-1,2,4-triazine.
Ridout & Maybee Llp
Torrent Pharmaceuticals Ltd.
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