C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/38 (2006.01) C07F 9/58 (2006.01) C07F 9/6506 (2006.01) C07F 9/6561 (2006.01)
Patent
CA 2642321
The present invention provides a novel process for preparation of bisphosphonic acid derivatives or pharmaceutical acceptable salt thereof, by reacting carboxylic acid having structural formula (II) with phosphorous acid and a halophosphorous compound, wherein halophosphorous compound is selected from the group comprising of PCl3, PCl5, POCl3, PBr3, POBr3, and PBr5 in presence of diphenyl ether.
La présente invention concerne un nouveau procédé de fabrication de dérivés d'acide biphosphonique ou de leurs sels pharmaceutiquement acceptables, par réaction d'acide carboxylique de formule structurale (II) avec de l'acide phosphoreux et un composé halogénophosphoreux, ledit composé halogénophosphoreux étant choisi dans le groupe comprenant PCl3, PCl5, POCl3, PBr3, POBr3 et PBr5, en présence d'éther diphénylique.
Deshpande Pandurang Balwant
Luthra Parven Kumar
Alembic Limited
Riches Mckenzie & Herbert Llp
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