An improved process for the preparation of entacapone

Details An improved process for the preparation of entacapone An improved process for the preparation of entacapone

C - Chemistry, Metallurgy

07

C

C07C 253/30 (2006.01)

Patent

CA 2661106

The present invention relates to an improved process for the preparation of Entacapone of formula (I): comprising a step of, condensation of 3, 4-dihydroxy-5- nitrobenzaldehyde of formula (II): with N, N-diethylcyanoacetamide of formula (III): in the presence of two component solvent system, a catalyst and optionally a phase transfer catalyst to give Entacapone of formula (I).

La présente invention concerne un procédé amélioré de préparation de l'entacapone de formule (I) comprenant une étape consistant en une condensation du 3,4-dihydroxy-5-nitrobenzaldéhyde de formule (II) avec du N,N-diéthylcyanoacétamide de formule (III) en présence d'un système solvant à deux composants, d'un catalyseur et, éventuellement, d'un catalyseur de transfert de phase, ce qui permet d'obtenir l'entacapone de formule (I).

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