An improved synthesis of ceftiofur intermediate

Details An improved synthesis of ceftiofur intermediate An improved synthesis of ceftiofur intermediate

C - Chemistry, Metallurgy

07

D

C07D 501/04 (2006.01) A61K 31/545 (2006.01) C07D 501/00 (2006.01)

Patent

CA 2471310

The present invention relates to a process for preparation of 7-amino-3-[2- (furylcarbonyl) thiomethyl]-3-cephem-4-carboxylic acid (I) by the condensation of 7-aminocephalosporanic acid (II) with furyl-2-carbonylthiol (III) in the presence of borontrifluoride or its complex, in an organic solvent or mixture of solvents at 0-50~C.

L'invention se rapporte à un procédé de préparation de 7-amino-3-[2-(furylcarbonyl) thiomethyl]-3-cephem-4-carboxylique acide (I) par condensation de 7-aminocephalosporanique acide (II) avec furyl-2-carbonylthiol (III) en présence de borontrifluoride ou son complexe, dans un solvant ou un mélange organique de solvants à 0-50·C.

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