A - Human Necessities – 01 – K
Patent
A - Human Necessities
01
K
A01K 67/027 (2006.01) A61K 49/00 (2006.01) C12N 5/00 (2006.01) C12N 15/85 (2006.01) G01N 33/00 (2006.01)
Patent
CA 2362585
Transgenic hairless mice which express a full length or truncated human elastin promoter and fibroblast cultures derived from these transgenic mice are provided. Also provided are methods of identifying compounds capable of inhibiting cutaneous photodamage with these transgenic hairless mice or fibroblast cultures derived from these mice. In addition, an in vitro system for identifying agents capable of inhibiting or preventing oxidative damage in these mice fibroblast culture wherein reactive oxygen species are generated within the mouse fibroblast culture and a method for identifying agents which prevent oxidative damage are provided.
L'invention a trait à des souris glabres transgéniques qui expriment un promoteur d'élastine humain en pleine longueur ou tronqué, et à des cultures fibroblastiques provenant de ces souris transgéniques. Cette invention concerne également des méthodes d'identification de composés qui peuvent inhiber la photodestruction cutanée de ces souris glabres transgéniques ou des cultures fibroblastiques provenant de ces souris. En outre, ladite invention concerne un système in vitro d'identification des agents qui peuvent inhiber ou prévenir la destruction oxydative dans cette culture fibroblastique, système dans lequel des espèces d'oxygène réactives sont générées au sein de ladite culture, et une méthode d'identification d'agents de prévention de la destruction oxydative.
Bernstein Eric F.
Borden Ladner Gervais Llp
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