An inducer of apoptosis

Details An inducer of apoptosis An inducer of apoptosis

C - Chemistry, Metallurgy

12

N

C12N 15/37 (2006.01) A61K 31/70 (2006.01) A61K 31/7088 (2006.01) A61K 38/16 (2006.01) A61K 39/12 (2006.01) A61K 48/00 (2006.01) A61P 15/00 (2006.01) A61P 31/20 (2006.01) A61P 35/00 (2006.01) C07K 14/025 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2455681

This invention relates to the use of a mutant E2 polypeptide to induce apoptosis (a form of programmed cell death) in cells. The mutant E2 derived polypeptide is p53 binding deficient. Preferably it is unable to bind p53; or able to bind p53 but unable to induce p53-dependent apoptosis.

L'invention concerne l'utilisation d'un polypeptide E2 mutant pour induire une apoptose (une forme de mort cellulaire programmée) dans des cellules. Ce polypeptide mutant dérivé d'E2 est déficient en liaison à p53, de préférence incapable de se lier à p53 ou capable de se lier à p53 mais incapable d'induire une apoptose p53-dépendante.

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