An insulinotropic complex using an immunoglobulin fragment

Details An insulinotropic complex using an immunoglobulin fragment An insulinotropic complex using an immunoglobulin fragment

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/26 (2006.01) A61K 47/48 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 15/08 (2006.01) C07K 14/575 (2006.01) C07K 14/605 (2006.01) C07K 16/00 (2006.01) C08G 65/329 (2006.01) C07K 17/08 (2006.01)

Patent

CA 2674538

The present invention relates to an insulinotropic peptide conjugate having improved in-vivo duration of efficacy and stability, comprising an insulinotropic peptide, a non-peptide polymer and an immunoglobulin Fc region, which are covalently linked to each other, and a use of the same. The insulinotropic peptide conjugate of the present invention has the in-vivo activity which is maintained relatively high, and has remarkably increased blood half- life, and thus it can be desirably employed in the development of long acting formulations of various peptide drugs.

La présente invention concerne un conjugué peptidique insulinotropique présentant une durée d'efficacité et de stabilité in vivo améliorée, contenant un peptide insulinotropique, un polymère non peptidique et une région d'immunoglobuline Fc, liés par covalence les uns aux autres, ainsi que l'utilisation dudit conjugué. Le conjugué peptidique insulinotropique de la présente invention présente une activité in vivo maintenue à un niveau relativement élevé et une demi-vie sanguine remarquablement supérieure, et peut être ainsi utilisé de manière désirée dans la mise au point de formulations à action prolongée de divers médicaments peptidiques.

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