An itraconazole exhibiting an improved solubility, a method...

Details An itraconazole exhibiting an improved solubility, a method... An itraconazole exhibiting an improved solubility, a method...

C - Chemistry, Metallurgy

07

D

C07D 403/14 (2006.01) A61K 31/41 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2294398

The particle diameter of itraconazole, insoluble drug, is reduced and crystallinity thereof is changed from crystalline into amorphous, increasing water solubility and a dissolution rate thereof . The improved itraconazole is applied to an oral adminstration drug.

Cette invention concerne un itraconazole, un médicament insoluble, qui possède des particules d'un diamètre réduit et dont la cristallinité est modifiée de manière à ce qu'elle passe d'un état cristallin à un état amorphe. Ce système permet d'accroître la solubilité de l'itraconazole dans l'eau ainsi que sa vitesse de dissolution. Cet itraconazole amélioré est appliqué sur un médicament que l'on administre par voie orale.

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