An oligonucleotide or its functional homologue, a...

Details An oligonucleotide or its functional homologue, a... An oligonucleotide or its functional homologue, a...

A - Human Necessities

61

K

A61K 31/7088 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07H 21/04 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2609067

The invention provides an oligonucleotide with a sequence of SEQ ID NO:1 or its functional homolgue, a composition comprising the same and a method for treating B cell neoplasm by using the oligonucleotide or its functional homologue or the composition comprising the oligonucleotide. The oligonulceotide induces the apoptosis of B cell neoplastic cells, up-regulates CD40 on B cell neoplastic cells and stimulates the production of IL-10 from B cell neoplastic cells.

L~invention concerne un oligonucléotide avec une séquence de SEQ ID NO:1 ou son homologue fonctionnel, une composition le comprenant et un procédé pour le traitement d~une tumeur cancéreuse à lymphocytes B en utilisant l~oligonucléotide ou son homologue fonctionnel ou la composition comprenant l~oligonucléotide. L~oligonucléotide induit l~apoptose des cellules néoplasiques à lymphocytes B, régule par le haut le CD40 sur les cellules néoplasiques à lymphocytes B et stimule la production d~IL-10 à partir des cellules néoplasiques à cellules B.

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