An oncolytic adenovirus

Details An oncolytic adenovirus An oncolytic adenovirus

C - Chemistry, Metallurgy

12

N

C12N 15/63 (2006.01) A61K 35/76 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12N 7/01 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2545696

Viral vectors and methods of making such vectors are described that preferentially kill neoplastic but not normal cells, the preferred vector being an adenovirus that has the endogenous promoters in the E1A and/or E4 regions substituted with a tumor specific promoter which is preferably E2F responsive.

La présente invention concerne des vecteurs viraux et des méthodes permettant d'élaborer de tels vecteurs, lesquels vecteurs, de préférence, tuent les cellules néoplasiques mais pas les cellules normales. Le vecteur privilégié dans cette invention est un adénovirus dont les promoteurs endogènes dans les régions E1A et/ou E4 sont substitués par un promoteur spécifique des tumeurs qui est, de préférence, sensible à E2F.

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